Database research record2025·Bangladesh
Genomics and Network Analysis of Multidrug-Resistant Shigella flexneri from Raw Vegetables in Bangladesh for Risk Assessment and Targeted Therapeutic Intervention
K M Tanjida Islam, Md Shahin Mahmud
Pharmacon Jurnal Farmasi Indonesia
Urban Farm DB summary
This study characterized multidrug-resistant (MDR) Shigella flexneri strains from contaminated raw vegetables in Bangladesh, retrieved from the NCBI genome database. Whole-genome sequences of four S. flexneri strains from tomatoes and green chilies in Gazipur and Dhaka were analyzed. The analysis identified 4273 core genes and 44 antibiotic resistance genes, with five essential hub genes (tolC, acrA, emrK, emrB, evgS) identified as high-priority therapeutic targets for compromising MDR mechanisms in food-borne S. flexneri.